Informed Consent for Testosterone Replacement Therapy DudeMeds – Issued by LocumTele (Medical Group) Effective Date: August 8, 2026 – Version 2.0 (supersedes January 1, 2024 version) 1. Consent to Treatment You consent to receive Testosterone Replacement Therapy ("TRT") from LocumTele, an independent professional medical entity (the "Medical Group"), and the licensed healthcare providers it engages. DudeMeds is the commerce and services brand through which you access the Medical Group; DudeMeds does not practice medicine, does not employ your providers, and does not direct your treatment. Depending on your provider's clinical judgment, TRT may be administered via injection, oral formulation, gel, cream, or other formulation. 2. Nature of Treatment and Provider Discretion All treatment decisions, including whether to prescribe testosterone at all, which formulation, at what dosage, and whether to prescribe adjunctive medications such as anastrozole (an aromatase inhibitor), hCG, or enclomiphene, are made solely by your licensed provider based on your medical history, symptoms, and laboratory results. You affirm that you have accurately and completely disclosed your medical, surgical, and family history and all medications and supplements you take. Providing false, misleading, or incomplete information, including inaccurate age or undisclosed medical history, can cause serious harm to your health and may result in denial or termination of treatment. 3. Risks and Side Effects TRT carries potential risks and side effects. Not all risks can be predicted or listed. Known risks include, but are not limited to: • Erythrocytosis / polycythemia: an increase in red blood cell count and hematocrit, which can thicken the blood and increase the risk of blood clots; this is monitored by lab testing and may require dose adjustment, temporary discontinuation, or therapeutic phlebotomy. • Cardiovascular effects: potential effects on blood pressure, and a possible association with cardiovascular events in certain patients; tell your provider about any history of heart disease, stroke, or blood clots. • Venous thromboembolism: blood clots in the legs (DVT) or lungs (pulmonary embolism). Seek emergency care for leg swelling or pain, chest pain, or sudden shortness of breath. • Fertility suppression: TRT suppresses LH and FSH and can significantly reduce sperm production, in some cases persistently. TRT is generally not appropriate if you are actively trying to conceive; discuss fertility-preserving alternatives with your provider. • Testicular atrophy: reduction in testicular size during therapy. • Estrogen-related effects: elevated estradiol, which may cause gynecomastia (breast tissue growth), nipple tenderness, fluid retention, or mood changes. • Prostate considerations: TRT is contraindicated in known or suspected prostate cancer and in male breast cancer; PSA and prostate symptoms will be monitored, and TRT may worsen urinary symptoms from benign prostatic enlargement. • Sleep apnea: TRT may worsen existing obstructive sleep apnea. • Skin and injection-related effects: acne, oily skin, hair changes, and, for injectable formulations, injection site pain, redness, bruising, or infection. • Liver effects: certain formulations carry risk of liver inflammation or injury; liver enzymes are monitored as clinically necessary. • Mood and behavioral effects: irritability, aggression, anxiety, or mood swings in some patients. • Lipid and metabolic changes: changes in cholesterol and other metabolic markers. Stopping TRT may result in a return or worsening of the symptoms that led you to seek treatment, and in a temporary period of low testosterone while your natural production recovers. Treatment outcomes are not guaranteed. 4. Controlled Substance Disclosure Testosterone is a Schedule III controlled substance under federal law. Accordingly: (a) your identity will be verified before prescribing; (b) prescriptions are issued and refilled only per your provider's orders, and early refills, replacement of misused product, and transfer of medication to any other person are prohibited; (c) your prescription information may be reported to and reviewed in state prescription drug monitoring programs as required by law; and (d) the availability of controlled substance prescribing via telehealth is subject to federal and state law, including federal telehealth prescribing rules that are subject to change. If changes in law require an in-person evaluation or other steps to continue your therapy, the Medical Group will notify you of the requirements, and continued treatment will be conditioned on satisfying them. 5. Compounded Medications Some medications prescribed in your protocol may be compounded formulations prepared by licensed compounding pharmacies. Compounded drugs are permitted under federal law but are not FDA-approved, meaning the FDA has not evaluated those specific formulations for safety, effectiveness, or quality. Your provider will discuss alternatives with you where clinically relevant. 6. Monitoring and Your Responsibilities Safe TRT requires ongoing laboratory monitoring, including testosterone levels, hematocrit and red blood cell count, PSA, estradiol, cholesterol, and liver enzymes as clinically indicated. Follow-up labs and provider reviews are required at the intervals directed by your provider, typically approximately every 90 days. You agree to complete required labs on schedule, attend follow-up reviews, take medication only as prescribed, and promptly report new symptoms, side effects, or changes in your health. Failure to complete required monitoring may result in your provider pausing or discontinuing your prescriptions for safety reasons; commercial consequences of a monitoring lapse are governed by the Terms of Sale. 7. Lifestyle Considerations TRT is most effective when combined with regular exercise, a balanced diet, adequate sleep, smoking cessation, and moderation of alcohol intake. TRT is not a substitute for management of underlying conditions contributing to your symptoms. 8. Program Structure and Commercial Terms TRT programs, including bundled plans such as the All-Inclusive Commit Kit, include medical consultation, laboratory testing, provider evaluation, diagnostic review, technology access, and fulfillment support. Bundled pricing is all-inclusive regardless of which medications, if any, are ultimately prescribed; adjunctive medications are included only if your provider determines they are clinically appropriate, and no refund, credit, or discount is issued because a particular medication was not clinically warranted, as described in the Terms of Sale. All pricing, billing, automatic renewal, cancellation, pause, refund, and shipping terms, including the refund stages that apply before and after laboratory services, evaluation, and shipment, are governed exclusively by the DudeMeds Terms of Sale, which you accept separately. In the event of any conflict between this Informed Consent and the Terms of Sale regarding commercial terms, the Terms of Sale control. In the event of any conflict regarding clinical matters, this Informed Consent controls. 9. Alternatives and Right to Decline Alternatives to TRT include no treatment, lifestyle modification, treatment of underlying conditions, and, for some patients, medications that stimulate natural testosterone production. You have the right to decline treatment, to ask questions, and to withdraw this consent and discontinue therapy at any time by notifying your provider; your provider may recommend a tapering or monitoring plan on discontinuation. 10. Final Acknowledgment By continuing, you confirm that you have read and understood this Informed Consent in full, that you have had the opportunity to ask questions and have had them answered to your satisfaction, and that you consent to Testosterone Replacement Therapy as determined appropriate by your licensed provider through the Medical Group.